文章詳情
寰樞椎長期乳酸堆積對老年小鼠學習記憶能力的影響
日期：2025-05-13 17:56
瀏覽次數：2096
摘要：
[摘 要] 目的: 觀察寰樞椎長期乳酸堆積對老年小鼠學習記憶能力的影響。方法: 小鼠寰樞椎間注射 30 %乳
酸溶液 15 d , 用跳台法、水迷宮法和洞板實驗測試其學習、記憶能力的改變 , 計算腦指數 , 做 HE染色觀察其
病理改變。結果: 與對照組比較 , 模型組小鼠跳台實驗中潛伏期和錯誤次數明顯增加 ( P < 0101) , 小鼠水迷宮
實驗中遊全程時間和錯誤次數也顯著增加 ( P < 0101) 。洞板實驗中模型組小鼠潛伏期延長 , 探洞次數減少
( P < 0101) 。 模型組小鼠腦指數減小 ( P < 0101) , HE染色發現其海馬區死亡細胞增多 , 出現了膠質小結 , 以及
血管周圍炎性細胞浸潤。結論: 頸部乳酸慢性堆積可以導致小鼠學習記憶功能障礙。
[關鍵詞] 乳酸; 學習記憶; 寰樞椎關節; 動物 , 實驗
Effects of accumulation of lactic acid in atlanto2 axial joint on abil ities
of learning and memory in senile mice
L IN Gui2miao , ZHAO Hong2yan , FAN Wen2jing , TIAN Yuan2tong , SUN Lian2kun , ZHAO Li2juan 3
(Department of Pathophysiology , School of Basic Medical Sciences , J ilin University , Changchun 130021 , China)
Abstract : Objective To observe the changes of learning and memory abilities induced by cumulative lactic acid for
long time in atlas dentata vertebrae in mice. Methods 30 % lactic acid was injected into the place between the first
and the second cervical vertebrae. The changes of lesarning and memory in mice were observed with step2down
avoidance test , water2maze test and hole2board test . The organ index of the brain was calculated and the
pathological changes were observed. Re sults In step2down avoidance test , the reaction period prolonged and wrong
times increased obviously ( P < 0101) , and the latency period shortened significantly 1 The whole2distance swimming
time prolonged and mistakes increased in water2maze test ( P < 0101) 1 In hole2board test , the latency period
prolonged and the times of extending the holes decreased significantly ( P < 0101) 1 The organ index of model mice
decreased significantly ( P < 0101) , and pathological changes such as the colloid corpuscle , necrotic cells increasing ,
inflammation cells infilt rating in blood vessels were discovered. Conclusion The abilities of learning and memory of
the model mice are hurt significantly by accumulation of lactic acid in cervical part .
酸溶液 15 d , 用跳台法、水迷宮法和洞板實驗測試其學習、記憶能力的改變 , 計算腦指數 , 做 HE染色觀察其
病理改變。結果: 與對照組比較 , 模型組小鼠跳台實驗中潛伏期和錯誤次數明顯增加 ( P < 0101) , 小鼠水迷宮
實驗中遊全程時間和錯誤次數也顯著增加 ( P < 0101) 。洞板實驗中模型組小鼠潛伏期延長 , 探洞次數減少
( P < 0101) 。 模型組小鼠腦指數減小 ( P < 0101) , HE染色發現其海馬區死亡細胞增多 , 出現了膠質小結 , 以及
血管周圍炎性細胞浸潤。結論: 頸部乳酸慢性堆積可以導致小鼠學習記憶功能障礙。
[關鍵詞] 乳酸; 學習記憶; 寰樞椎關節; 動物 , 實驗
Effects of accumulation of lactic acid in atlanto2 axial joint on abil ities
of learning and memory in senile mice
L IN Gui2miao , ZHAO Hong2yan , FAN Wen2jing , TIAN Yuan2tong , SUN Lian2kun , ZHAO Li2juan 3
(Department of Pathophysiology , School of Basic Medical Sciences , J ilin University , Changchun 130021 , China)
Abstract : Objective To observe the changes of learning and memory abilities induced by cumulative lactic acid for
long time in atlas dentata vertebrae in mice. Methods 30 % lactic acid was injected into the place between the first
and the second cervical vertebrae. The changes of lesarning and memory in mice were observed with step2down
avoidance test , water2maze test and hole2board test . The organ index of the brain was calculated and the
pathological changes were observed. Re sults In step2down avoidance test , the reaction period prolonged and wrong
times increased obviously ( P < 0101) , and the latency period shortened significantly 1 The whole2distance swimming
time prolonged and mistakes increased in water2maze test ( P < 0101) 1 In hole2board test , the latency period
prolonged and the times of extending the holes decreased significantly ( P < 0101) 1 The organ index of model mice
decreased significantly ( P < 0101) , and pathological changes such as the colloid corpuscle , necrotic cells increasing ,
inflammation cells infilt rating in blood vessels were discovered. Conclusion The abilities of learning and memory of
the model mice are hurt significantly by accumulation of lactic acid in cervical part .
