用大鼠静脉自身给**法评价盐酸***的

摘要 　 目的:评价盐酸***的精神依赖性潜力。方法:大鼠静脉自身给药法。结果:与生理盐水自身对照相比 ,
盐酸***在点燃剂量015 mg· kg- 1
和梯度剂量0125 mg· kg- 1
下 ,触鼻次数显著增加 , P < 01001 , 均形成稳定的自
身给药行为;而两种不同剂量下盐酸***的日摄入总量(total daily dose , TDD)无显著性差异。结论:盐酸***
具有较强的精神依赖性潜力。
关键词 　 静脉自身给药; 盐酸***; 精神依赖性
ASSESSMENT OF OXYCODONE HYDROCHLORIDE INDUCED PSYCHIC DEPENDENCE
BY INTRAVENOUS SELF - ADMINISTRATION IN RATS
HA Ying , WANGWeiping
( National Institute on Drug Dependence , Peking University , Beijing , 100083)
ABSTRACT 　Objective : To assess the psychic dependence potential of oxycodone hydrochloride.
Methods : The technique of intravenous self - administration by rats was utilized. Under fixed - ratio = 1
schedule of drug injection , one nose - poke response result in drug delivery to the rat . Results : All the rats
trained with oxycodone at dose 015 mg· kg - 1
showed self - administration behavior. The number of nose - poke
response to oxycodone was much more than that to saline ( P < 01001) . As the dose of oxycodone hydrochlo2
ride lowered to 0125 mg· kg- 1
, the number of nose - poke response to oxycodone increased significantly ( P <
01001) , while the total daily dose (TDD) of oxycodone hydrochloride infusions changed insignificantly ( P >
0105) . Conclusion : Oxycodone hydrochloride has psychological dependence potential .
KEY WORDS　self - administration ; oxycodone hydrochloride ; psychological dependence