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寰枢椎长期乳酸堆积对老年小鼠学习记忆能力的影响

日期:2024-03-29 13:40
浏览次数:1848
摘要:
[摘   要]   目的: 观察寰枢椎长期乳酸堆积对老年小鼠学习记忆能力的影响。方法: 小鼠寰枢椎间注射 30 %乳
酸溶液 15 d , 用跳台法、水迷宫法和洞板实验测试其学习、记忆能力的改变 , 计算脑指数 , 做 HE染色观察其
病理改变。结果: 与对照组比较 , 模型组小鼠跳台实验中潜伏期和错误次数明显增加 ( P < 0101) , 小鼠水迷宫
实验中游全程时间和错误次数也显著增加 ( P < 0101) 。洞板实验中模型组小鼠潜伏期延长 , 探洞次数减少
( P < 0101) 。 模型组小鼠脑指数减小 ( P < 0101) , HE染色发现其海马区死亡细胞增多 , 出现了胶质小结 , 以及
血管周围炎性细胞浸润。结论: 颈部乳酸慢性堆积可以导致小鼠学习记忆功能障碍。
[关键词]   乳酸; 学习记忆; 寰枢椎关节; 动物 , 实验
Effects of accumulation of lactic acid in atlanto2 axial joint on abil ities
of learning and memory in senile mice
L IN Gui2miao , ZHAO Hong2yan , FAN Wen2jing , TIAN Yuan2tong , SUN Lian2kun , ZHAO Li2juan 3
(Department of Pathophysiology , School of Basic Medical Sciences , J ilin University , Changchun 130021 , China)
Abstract : Objective  To observe the changes of learning and memory abilities induced by cumulative lactic acid for
long time in atlas dentata vertebrae in mice. Methods 30 % lactic acid was injected into the place between the first
and the second cervical vertebrae. The changes of lesarning and memory in mice were observed with step2down
avoidance test , water2maze test and hole2board test . The organ index of the brain was calculated and the
pathological changes were observed. Re sults  In step2down avoidance test , the reaction period prolonged and wrong
times increased obviously ( P < 0101) , and the latency period shortened significantly 1 The whole2distance swimming
time prolonged and mistakes increased in water2maze test ( P < 0101) 1 In hole2board test , the latency period
prolonged and the times of extending the holes decreased significantly ( P < 0101) 1 The organ index of model mice
decreased significantly ( P < 0101) , and pathological changes such as the colloid corpuscle , necrotic cells increasing ,
inflammation cells infilt rating in blood vessels were discovered. Conclusion The abilities of learning and memory of
the model mice are hurt significantly by accumulation of lactic acid in cervical part .

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